HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1585290Generated: October 26, 2026
Diethyl Ether → 2-[5-(2,6-Dimethoxyphenyl)-1-[4-[n-methyl-n-(3-dimethylaminopropyl)carbamoyl]-2-isopropylphenyl]-3-pyrazolylcarbonylamino]-2-adamantanecarboxylic acid sodium salt
https://huagongshe.com/reaction/1585290
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | SR142948A | HCID 5311451 | — |
| Reactant | Sodium Methoxide | HCID 10942334 | — |
| Catalyst | Dichloromethane | HCID 6344 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-[5-(2,6-Dimethoxyphenyl)-1-[4-[n-methyl-n-(3-dimethylaminopropyl)carbamoyl]-2-isopropylphenyl]-3-pyrazolylcarbonylamino]-2-adamantanecarboxylic acid sodium salt | HCID 70244978 | 70.6% |
Reaction Steps
0.206 g of the compound obtained in EXAMPLE 1' and 0.026 g of sodium methylate are dissolved in 1 ml of MeOH and a few drops of DCM, and this solution is then poured into 50 ml of ether cooled to 5° C. The gelatinous precipitate formed is drained and dried over P2O5 and under vacuum. 0.15 g of the expected product is obtained, m.p.=191° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05936123 |
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| Source dataset | uspto-grants-1999_08 |
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| ORD ID | ord-c8c9b0d2a0414d5faa6211f00adb7c29 |
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| Source note | uspto-grants-1999_08 |
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