Lithium Hydroxide → HCID 22876407, compound

Participants

Reaction Steps

In analogy with Example 5e), 6.7 g (10.83 mmol) of 5(S)-[1(S)-(Boc-amino)-2-phenylethyl]-3(R)-{[p-(2,6-dichlorobenzylsulfonyl)phenyl]methyl}dihydrofuran-2-(3H)-one in 170 ml of dimethoxyethane are hydrolysed with 43.3 ml of a 1 M lithium hydroxide solution (RT, 17 h). Partitioning between 3× methylene chloride, NH4Cl/citric acid solution and saline, and stirring the crude product in ether, affords the title compound: tRet (II)=15.5 min.

Provenance & Evidence