HCID 15434401, compound → HCID 9889997, compound

Participants

Reaction Steps

To a Parr hydrogenation flask containing 3.7 mg of 10% Pd/C was added a solution of 50 mg (0.080 mmol) of 3-[(5-chloro-2-[[bis[phenylmethyl]phosphono]oxy]phenyl)methyl]-5-[4-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2(3H)-one dissolved in 2 mL of ethyl acetate and 5 mL of ethanol. The mixture was hydrogenated at 40 psi for 40 minutes, filtered through celite and the filtrate was concentrated to give 35 mg of 3-[(5-chloro-2-[phosphonooxy]phenyl)methyl]-5-[4-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2(3H)-one as a white solid: m.p. 173-176° C. MS 449 (M--H)-.

Provenance & Evidence