Tetrahydrofuran → HCID 15434404, compound

Participants

Reaction Steps

A solution of 3-[[5-chloro-2-[[[[bis-(phenylmethyl)phosphonooxy]methyl]carbonyl]oxy]phenyl]methyl]-5-[4-(trifluoromethyl)phenyl]- 1,3,4 -oxadiazol-2(3H)-one (138 mg, 0.20 mmol) in ethyl acetate (30 mL) and PtO2 (30 mg) was hydrogenated at 30 psi in a Parr apparatus for 1 hr. After hydrogenation is complete, THF (30 mL) was added to solublize the product and then filtered through a pad of Celite to remove the catalyst. The filtrate was evaporated and the residue was recrytallized twice from ether-hexanes and then acetone-hexanes to afford the title compound as a white powder (83 mg, 82%). MS m/e 509 (MH+).

Provenance & Evidence