HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Piperidineethanol → benzyl N-[4-(2-hydroxyethyl)piperidine-1-carboximidoyl]carbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Piperidineethanol | HCID 73953 | — |
| Reactant | Benzyl [amino(methylsulfanyl)methylene]carbamate | HCID 140362141 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | benzyl N-[4-(2-hydroxyethyl)piperidine-1-carboximidoyl]carbamate | HCID 140379078 | 41% |
Reaction Steps
A mixture of 6.2 g (0.028 mol) of 4-hydroxyethyl piperidine and 3.6 g (0.028 mol) of N-benzyloxycarbonyl-S-methyl isothiourea in 50 ml of acetonitrile was refluxed overnight. Evaporation and flash chromatography on silica gel with ethyl acetate gave 3.5 g (41%) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05939392 |
| Source dataset | uspto-grants-1999_08 |
| ORD ID | ord-528a6f32c04c4a6e937f8d64bce1ca75 |
| Source note | uspto-grants-1999_08 |