Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | tert-Butanol | HCID 6386 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | HCID 10673254 | HCID 10673254 | — |
| Solvent | Water | HCID 962 | — |
| Product | 86023-87-2 | HCID 158910 | — |
Reaction Steps
A glass lined reactor was charged with 12.4 Kg of (3β,5α,11β,25R)-11-bromospirostan-3-ol-12-one (24.34 mole), 33 gallons of t-butanol, 33 gallons of water and 7.5 Kg (189 mole, 7.75 eq) of sodium hydroxide pellets. The reaction was heated to reflux over 1.5 hours, maintained at -reflux for 4.5 hours (pot temperature was 83° C.), then cooled to room temperature. TLC at this point indicated complete reaction.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05939398 |
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| Source dataset | uspto-grants-1999_08 |
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| ORD ID | ord-ba9629a5c78d4b599847c0508d30ec4f |
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| Source note | uspto-grants-1999_08 |
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