Nitrogen → HCID 21218650, compound

Participants

Reaction Steps

At a 170-180° C. bath temperature, in a protective atmosphere of N2, 4-(4-chlorophenyl)-1-(2,2-dimethyl-3-hydroxypropyl)-3-phenyl-1,5-dihydro-pyrrol-2-on (5, 10.7 g, 0.03 mol) is melted with phosphorus pentasulfide (3.33 g, 2.5 equiv., 0.015 mol), which is added in small portions until the gas development comes to a halt (1 h). Then the cooled reaction mixture is akalyzed with caustic soda (100 mL, 10%) and extracted with chloroform; the organic phase is washed with water and dried. The residue remaining after the evaporation of chloroform is crystallized from diisopropyl ether having a melting point of 147-148° C. (5.5 g, 52%).

Provenance & Evidence