Quinoline → HCID 21219138, compound

Participants

Reaction Steps

The title compound was prepared by the procedure described in step 1 of Example 1 using 13.0 g of quinoline, 39.0 g of 4-fluorobenzoyl chloride, 0.1 g of aluminum chloride, 30.0 g of trimethyl silyl cyanide, and 500 mL of methylene chloride. The title compound (42.0 g) was obtained as a solid, m. p. 111-113° C. This product was used for the preparation of the title compound described in step 2, and for preparation of the title compound described in Example 4.

Provenance & Evidence