Quinoline → HCID 21219136, compound

Participants

Reaction Steps

The title compound was prepared by the procedure described in step 1 of Example 1 using 13.0 g of quinoline, 32.0 g of 4-trifluoromethylbenzoyl chloride, 0.5 g of aluminum chloride, 14.8 g of trimethyl silyl cyanide, and 500 mL of methylene chloride. Crystallization from diethyl ether/hexane afforded the title compound (28.0 g) as a white solid, m. p. 149-151° C. This product was used for the preparation of the title compound described in step 2, and for preparation of the title compound described in Example 6.

Provenance & Evidence