Sodium Hydroxide → HCID 18424181, compound

HRID 1585589Notes

Reaction equation

HRID 1585589 reaction equation
[N+:1]([C:4]1[CH:23]=[CH:22][C:7]([C:8]([C:10]2[N:14]([CH3:15])[C:13]([CH2:16][C:17]([O:19]CC)=[O:18])=[CH:12][CH:11]=2)=[O:9])=[CH:6][CH:5]=1)([O-:3])=[O:2].[OH-].[Na+]>C(O)C>[N+:1]([C:4]1[CH:23]=[CH:22][C:7]([C:8]([C:10]2[N:14]([CH3:15])[C:13]([CH2:16][C:17]([OH:19])=[O:18])=[CH:12][CH:11]=2)=[O:9])=[CH:6][CH:5]=1)([O-:3])=[O:2]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 18424238HCID 18424238, compound

Product 1

HCID 18424181HCID 18424181, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 3.2 g. (0.01 mole) of ethyl 5-(p-nitrobenzoyl)-1-methylpyrrole-2-acetate and 25 ml. ethanol is brought to reflux. To this is added dropwise 10 ml. of 1N sodium hydroxide solution. After the addition is complete, the ethanol is evaporated and the residue is acidified with dilute hydrochloric acid. The resulting solid, 5-(p-nitrobenzoyl)-1-methylpyrrole-2-acetic acid, is separated by filtration and purified by recrystallization from ethanol, m.p. 192-195° C.

Workup

  1. temperatureto reflux
  2. additionTo this is added dropwise 10 ml
  3. additionAfter the addition
  4. customthe ethanol is evaporated
  5. customThe resulting solid, 5-(p-nitrobenzoyl)-1-methylpyrrole-2-acetic acid, is separated by filtration
  6. custompurified by recrystallization from ethanol, m.p. 192-195° C.

Sources & evidence

ORD record
ord-c3370973809d4c39a045d761a8ff42d9
Source dataset
uspto-grants-1999_08
Patent number
US05939417

Reaction notes

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