2-Methylpiperazine, (S)- → 2-Methyl-5-[(3S)-3-methyl-1-piperazinyl]quinoline

HRID 15856Notes

Reaction equation

HRID 15856 reaction equation
[CH3:1][C@H:2]1[CH2:7][NH:6][CH2:5][CH2:4][NH:3]1.FC(F)(F)S(O[C:14]1[CH:23]=[CH:22][CH:21]=[C:20]2[C:15]=1[CH:16]=[CH:17][C:18]([CH3:24])=[N:19]2)(=O)=O>>[CH3:24][C:18]1[CH:17]=[CH:16][C:15]2[C:20](=[CH:21][CH:22]=[CH:23][C:14]=2[N:6]2[CH2:5][CH2:4][NH:3][C@@H:2]([CH3:1])[CH2:7]2)[N:19]=1

Participants

3

Reactant 2

HCID 27342192-Methylpiperazine, (S)-HCID 498518992-Methylquinolin-5-yl trifluoromethanesulfonate

Product 1

HCID 574443412-Methyl-5-[(3S)-3-methyl-1-piperazinyl]quinolineYield 27%

Procedure

The title compound was prepared in 27% yield using a similar procedure to Example 127 starting from (2S)-2-methylpiperazine and 2-methyl-5-quinolinyl trifluoromethanesulfonate (D1).

Sources & evidence

ORD record
ord-999e9664e7c64827b2c9f24781bc1440
Source dataset
uspto-grants-2010_06
Patent number
US07732600B2

Reaction notes

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