Ethanol → HCID 18424167, compound

Participants

Reaction Steps

A suspension of 3.0 g. (0.009 mole) of 1-benzyl-5-(p-chlorobenzoyl)-pyrrole-2 -acetonitrile in 20 ml. of ethanol and 18 ml. (0.018 mole) of 1N sodium hydroxide is refluxed for 6 hours. The mixture is diluted with water, and the ethanol evaporated in vacuo. The solution is washed with chloroform and ether and acidified with 3N hydrochloric acid. The precipitated solid is collected and dried in vacuo to give 1-benzyl-5-(p-chlorobenzoyl)-pyrrole-2-acetic acid as white crystals, M.P. 162-163° C. Analysis: Calcd. for C20H15ClNO3 : C, 67.70; H, 4.65; N, 3.96%. Found: C, 67.79; H, 4.65; N, 3.97%.

Provenance & Evidence