Imidazole → HCID 18391463, compound

Participants

Reaction Steps

Imidazole (84 mg, 1.24 mmol) was added to a solution of BocIleProNH2 in dry pyridine (10 cm3), under a nitrogen atmosphere. The solution was cooled to -35° C., before the dropwise addition of POCl3 (0.25 cm3, 2.48 mmol). The reaction was stirred at -30° C. to -20° C. for 60 min. The solution was then evaporated and the crude residue subjected to column chromatography (silica gel) to yield 180 mg (94%) of 2-(S)-cyano-1-[N-(t-butoxycarbonyl)isoleucyl]pyrrolidine as a colourless oil.

Provenance & Evidence