反应详情

A solution of the ester from step 1 (0.098 g, 0.652 mmol), in ethanol (2.5 ml) at 0° C. was treated with sodium borohydride (0.11 g, 2.936 mmol) and the reaction was stirred for 2 hrs. Saturated NH4Cl solution (1 ml) was added and the aqueous extracted with diethylether. The combined extracts were dried (MgSO4) and evaporated in vacuo. The residue was chromatographed (silica gel, diethylether) to afford the title compound.

1. extractionthe aqueous extracted with diethylether
2. dry with materialThe combined extracts were dried (MgSO4)
3. customevaporated in vacuo
4. customThe residue was chromatographed (silica gel, diethylether)