反应详情

温度

60 °C

2-Bromomethyl-5-methoxy-benzonitrile from step 4 (70 mg, 0.30 mmol) and 5-chloro-5'-(1-trityl-1H-imidazol-4-ylmethyl)-[1,2']bipyridinyl-2-one from Example 23, Step 5 (200 mg, 0.378 mmol) were dissolved in CH3CN (2 ml) and heated to 60° C. for 16 hours. The solvent was removed in vacuo and redissolved in MeOH (2 ml). The reaction mixture was heated to 60° C. for several hours. Solvent was removed in vacuo and the resulting residue was purified by flash chromatography [4% MeOH(5% NH4OH )/CH2Cl2 ] to yield the final product.

1. customThe solvent was removed in vacuo
2. dissolutionredissolved in MeOH (2 ml)
3. temperatureThe reaction mixture was heated to 60° C. for several hours
4. customSolvent was removed in vacuo
5. customthe resulting residue was purified by flash chromatography [4% MeOH(5% NH4OH )/CH2Cl2 ]