反应详情

In a reaction vessel purged with nitrogen was weighed 14.0 g of sodium hydroxide (349 mmole), and suspended in 200 ml of toluene, to which 100 ml of a toluene solution of diethyl ethylmalonate (60.0 ml, 320 mmole) was added dropwise in an ice bath. After the addition was completed and the mixture was stirred at room temperature for 3 hours, 100 ml of a toluene solution of 2-bromobenzyl bromide (80.0 g, 320 mmole) was added dropwise, and the mixture was stirred overnight. The reaction was terminated by pouring the reaction mixture to dilute hydrochloric acid, and the organic layer was washed with water, dried and concentrated to give 120 g of diethyl 2-(2-bromobenzyl)-2-methylmalonate as a yellow oil (yield, 100%).

1. customIn a reaction vessel purged with nitrogen
2. additionwas added dropwise in an ice bath
3. additionAfter the addition
4. stirringthe mixture was stirred overnight
5. customThe reaction was terminated
6. additionby pouring the reaction mixture to dilute hydrochloric acid
7. washthe organic layer was washed with water
8. customdried
9. concentrationconcentrated
10. customto give