HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → Ethyl 3-(2-bromophenyl)-2-methylpropionate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Lithium Chloride | HCID 433294 | — |
| Reactant | Diethyl 2-(2-bromobenzyl)-2-methylmalonate | HCID 21217385 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | Ethyl 3-(2-bromophenyl)-2-methylpropionate | HCID 21217380 | 100.1% |
Reaction Conditions
| Temperature | 180 °C |
|---|
Reaction Steps
To a solution of diethyl 2-(2-bromobenzyl)-2-methylmalonate (108 g, 310 mmole) in dimethylsulfoxide (350 ml) were added 26.4 g of lithium chloride (620 mmole) and 5.6 ml of water (310 mmole). After stirring at 180° C. for 8 hours, the product was extracted with n-hexane and concentrated to give 84.1 g of ethyl 3-(2-bromophenyl)-2-methylpropionate as a yellow oil (yield, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05942459 |
| Source dataset | uspto-grants-1999_08 |
| ORD ID | ord-8d3aa1d4cc0c4858b4e0abb7a6c4038e |
| Source note | uspto-grants-1999_08 |