反应详情

温度

140 °C

To 52.5 g of 3-(2-bromophenyl)-2-methylpropionic acid (215 mmole) were added 210 g of polyphosphoric acid and 250 ml of o-dichlorobenzene, and the mixture was stirred at 140° C. for 6 hours. The mixture was diluted with 300 ml of water, and the product was extracted with n-hexane and ether, dried and concentrated, and the residual concentrate thus obtained was distilled to give 27.3 g of 4-bromo-2-methylindan-1-one as a colorless oil (yield, 56%).

1. extractionthe product was extracted with n-hexane and ether
2. customdried
3. concentrationconcentrated
4. concentrationthe residual concentrate thus
5. customobtained
6. distillationwas distilled
7. customto give