2-Acetylbutyrolactone → HCID 178463338、化合物

HRID 1586045ノート

反応式

HRID 1586045 の反応式
[NH2:1][C:2]1[CH:6]=[CH:5][NH:4][N:3]=1.[C:7]([CH:10]1[CH2:15][CH2:14][O:13][C:11]1=[O:12])(=O)[CH3:8]>C(O)C>[O:12]=[C:11]1[CH:10]([C:7](=[N:1][C:2]2[CH:6]=[CH:5][NH:4][N:3]=2)[CH3:8])[CH2:15][CH2:14][O:13]1

参加物

4

反応物 2

HCID 106012-AcetylbutyrolactoneHCID 178418806HCID 178418806、化合物

生成物 1

HCID 178463338HCID 178463338、化合物収率 69.4%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

In 12 ml of anhydrous ethanol were added 0.83 g (10.00 mmol) of 3-aminopyrazole and 1.92 g (15.00 mmol) of 2-acetyl-γ-butyrolactone. While stirring at room temperature, 0.1 ml of a boron trifluoride methanol complex were added to the resultant solution, and the mixture was then stirred for 4 hours under the same conditions. Solids deposited were collected by filtration, washed with ethanol and air-dried to obtain 1.34 g (yield: 69.4%) of the intended product.

後処理

  1. stirringthe mixture was then stirred for 4 hours under the same conditions
  2. filtrationSolids deposited were collected by filtration
  3. washwashed with ethanol
  4. customair-dried

出典と根拠

ORDレコード
ord-68ba034fc36d441f8b95449d92395754
出典データセット
uspto-grants-1999_08
特許番号
US05942515

反応ノート

読み込み中…