Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | 4-Phenoxybenzaldehyde | HCID 66139 | — |
| Reactant | 3,4-Diaminobenzonitrile | HCID 737285 | — |
| Reactant | Sodium Bisulfite | HCID 23665763 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 178509511 | HCID 178509511 | 57.8% |
Reaction Steps
To 4-phenoxybenzaldehyde (4.0 g, 0.020 mol) was added 20 mL of 40% NaHSO3 (aq). The mixture was stirred for 2 h at 25° C. 3,4-Diaminobenzonitrile (3.36 g, 0.0252 mol) and ethanol (50 mL) were added. The mixture was refluxed for 4 h. The reaction was then poured into water. The precipitate was filtered and recrystallized from ethyl acetate to afford 3.6 g (57%) of 2-(4-phenoxyphenyl)-1H-benzimidazole-5-nitrile.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05942532 |
|---|
| Source dataset | uspto-grants-1999_08 |
|---|
| ORD ID | ord-39f06c98bdf14f9c9044522d4eda635d |
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| Source note | uspto-grants-1999_08 |
|---|
