2,2,2-Trifluoro-1-(4-iodophenyl)ethanol → 2-(4-(2,2,2-Trifluoro-1-hydroxyethyl)phenyl)-8-(2-(trifluoromethyl)phenylsulfonyl)-2,8-diazaspiro[4.5]decan-1-one

HRID 158610Notes

Reaction equation

HRID 158610 reaction equation
[F:1][C:2]([c:3]1[c:4]([S:9](=[O:10])(=[O:11])[N:12]2[CH2:13][CH2:14][C:15]3([CH2:16][CH2:17][NH:18][C:19]3=[O:20])[CH2:21][CH2:22]2)[cH:5][cH:6][cH:7][cH:8]1)([F:23])[F:24].[F:25][C:26]([CH:27]([OH:28])[c:29]1[cH:30][cH:31][c:32]([I:35])[cH:33][cH:34]1)([F:36])[F:37]>>[F:1][C:2]([c:3]1[c:4]([S:9](=[O:10])(=[O:11])[N:12]2[CH2:13][CH2:14][C:15]3([CH2:16][CH2:17][N:18]([c:32]4[cH:31][cH:30][c:29]([CH:27]([C:26]([F:25])([F:36])[F:37])[OH:28])[cH:34][cH:33]4)[C:19]3=[O:20])[CH2:21][CH2:22]2)[cH:5][cH:6][cH:7][cH:8]1)([F:23])[F:24]

Participants

3

Reactant 2

HCID 594408652,2,2-Trifluoro-1-(4-iodophenyl)ethanolHCID 595779268-(2-Trifluoromethyl-benzenesulfonyl)-2,8-diaza-spiro[4.5]decan-1-one

Product 1

HCID 595779442-(4-(2,2,2-Trifluoro-1-hydroxyethyl)phenyl)-8-(2-(trifluoromethyl)phenylsulfonyl)-2,8-diazaspiro[4.5]decan-1-one

Sources & evidence

ORD record
ord-8bfedbe0df474f1abcbb009504b0ce76
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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