HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chloroform → HCID 18391504, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chloroform | HCID 6212 | — |
| Reactant | Sodium Cyanide | HCID 8929 | — |
| Reactant | HCID 14804603 | HCID 14804603 | — |
| Reactant | HCID 18391505 | HCID 18391505 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | HCID 18391504 | HCID 18391504 | — |
Reaction Steps
The tosylate 12 (2.02 g, 4.53 mmol) was treated with NaCN in DMSO at 80° C. to provide, after workup, the cis nitrile ester (0.88 g, 64%) as a colorless oil: [α]25D +32° (c 1.04, CHCl3); Spectra were identical in all respects to those of the enantiomer N-(benzyloxycarbonyl)-cis-4-cyano-L-proline ethyl ester; HRMS (EI, 22 eV) m/e 302.1255 (302.1266 calcd for C16H18NO4).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05942537 |
| Source dataset | uspto-grants-1999_08 |
| ORD ID | ord-4586575ec075446a8da370b094771a66 |
| Source note | uspto-grants-1999_08 |