HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → HCID 19592214, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | 2-Iodobenzoic acid | HCID 6941 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1-Ethyl-3-methyl-1H-pyrazol-5-amine | HCID 2768383 | — |
| Catalyst | Cupric acetate | HCID 8895 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 19592214 | HCID 19592214 | 98% |
Reaction Steps
A mixture of 2-iodobenzoic acid (14.88 g, 0.06 mol), 1-ethyl-3-methyl-5-aminopyrazole (7.5 g, 0.06 mol), DMF (50 ml), Cu(OAc)2. H2O (0.5 g) and potassium carbonate (8.3 g, 0.06 mol) is refluxed for 20 hours. The reaction mixture is cooled to room temperature, poured into ice waterl and neutralized with acetic acid. A solid forms which is collected by filtration, washed with water and dried to give 7.1 g (98%) of N-(1-ethyl-3-methylpyrazol-5-yl) anthranilic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05942520 |
| Source dataset | uspto-grants-1999_08 |
| ORD ID | ord-0bd142b2bed14181b0867b7f332a69c1 |
| Source note | uspto-grants-1999_08 |