HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 2-Bromo-5-methoxybenzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 3-Methoxybenzoic Acid | HCID 11461 | — |
| Reactant | Bromine | HCID 24408 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 2-Bromo-5-methoxybenzoic acid | HCID 89906 | — |
Reaction Steps
To m-anisic acid in acetic acid (1 L) is added dropwise bromine (85 ml), followed by water (1 L). The reaction mixture is heated to reflux, cooled in an ice-bath and then the product is collected by filtration, washed with cold water and dried to afford 2-bromo-5-methoxybenzoic acid, m.p. 154°-156° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05942520 |
| Source dataset | uspto-grants-1999_08 |
| ORD ID | ord-8d046ca980d34776adde257706b20740 |
| Source note | uspto-grants-1999_08 |