HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonium Hydroxide → 1-ethyl-4-chloro-6-methoxy-1H-pyrazolo[3,4-b]quinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonium Hydroxide | HCID 14923 | — |
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | N-(1-ethylpyrazol-5-yl)-5-methoxyanthranilic acid | HCID 19592240 | — |
| Product | 1-ethyl-4-chloro-6-methoxy-1H-pyrazolo[3,4-b]quinoline | HCID 19592212 | — |
Reaction Steps
A mixture of N-(1-ethylpyrazol-5-yl)-5-methoxyanthranilic acid (27.5 g, 0.105 mol) and POCl3 (60 ml) is refluxed overnight. The reaction mixture is poured into ice waterl, basified with NH4OH and the solid which forms is collected by filtration to afford 20 g of 4-chloro-1-ethyl-6-methoxy-1H-pyrazolo[3,4-b]quinoline.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05942520 |
| Source dataset | uspto-grants-1999_08 |
| ORD ID | ord-ce911e17de12486a8b5548ad7d69d6f0 |
| Source note | uspto-grants-1999_08 |