Ammonium Hydroxide → 1-phenylmethyl-4-chloro-1H-pyrazolo[3,4-b]quinoline

Participants

Reaction Steps

A mixture of N-(1-phenylmethylpyrazol-5-yl) anthranilic acid (6 g) and POCl3 (60 ml) is heated on a steam bath overnight. The reaction mixture is poured into ice waterl, neutralized with NH4OH, and the precipitate which forms is collected by filtration,washed with water and dried to afford 5 g of 1-phenylmethyl-4-chloro-1H-pyrazolo[3,4-b]quinoline, as a light brown powder.

Provenance & Evidence