反应详情

温度

110 °C

A mixture of 4-chloro-1-ethyl-1H-pyrazolo[3,4-b]quinoline (1 g), DMSO (3 ml) and adamantylmethylamine (1 g) is heated at 110° C. overnight. The reaction mixture is poured into water, and a precipitate forms which is collected by filtration and dried to afford the product as a free base. The free base is treated with methanesulfonic acid/methanol, the methanol is evaporated and the salt is recrystallized from 2-propanol to afford 290 mg of 1-ethyl-N-(adamantylmethyl)-1H-pyrazolo[3,4-b]quinolin-4-amine.CH3SO3H, m.p. 310° C.

1. filtrationa precipitate forms which is collected by filtration
2. customdried
3. customto afford the product as a free base
4. customthe methanol is evaporated
5. customthe salt is recrystallized from 2-propanol