HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonium Hydroxide → 1-ethyl-4-chloro-6-nitro-1H-pyrazolo[3,4-b]quinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonium Hydroxide | HCID 14923 | — |
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | N-(1-ethylpyrazol-5-yl)-5-nitroanthranilic acid | HCID 21217728 | — |
| Product | 1-ethyl-4-chloro-6-nitro-1H-pyrazolo[3,4-b]quinoline | HCID 21217713 | 65% |
Reaction Steps
A mixture of N-(1-ethylpyrazol-5-yl)-5-nitroanthranilic acid (3.8 g, 13.77 mmol) and POCl3 (20 ml) is refluxed for 8 hours. The reaction mixture is poured into ice waterl, neutralized with concentrated NH4OH, and the resulting solid is collected by filtration, washed with water and dried to afford 2.5 g (65%) of 1-ethyl-4-chloro-6-nitro-1H-pyrazolo[3,4-b]quinoline.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05942520 |
| Source dataset | uspto-grants-1999_08 |
| ORD ID | ord-95f36b1a90a440b0a40c370882d15704 |
| Source note | uspto-grants-1999_08 |