Ammonium Hydroxide → 1-ethyl-4-chloro-6-bromo-1H-pyrazolo[3,4-b]quinoline

참여 물질

반응 단계

A mixture of N-(1-ethylpyrazol-5-yl)-5-bromoanthranilic acid (12.6 g) and POCl3 (30 ml) is refluxed overnight. The reaction mixture is poured into ice water (500 ml), stirred for 20 minutes, and then NH4OH is added until a pH of 8-10 is obtained. The mixture is stirred for 0.5 hours, and then the solid that forms is collected by filtration. The solid is dissolved in CH2Cl2, dried over MgSO4 and purified by column chromatography on silica gel eluting with 30% hexane/ethyl acetate to afford 6.5 g of 1-ethyl-4-chloro-6-bromo-1H-pyrazolo[3,4-b]quinoline, m.p. 117°-118° C.

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