HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → HCID 21217699, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1-Ethyl-1H-pyrazol-5-amine | HCID 337310 | — |
| Reactant | 2-Chloro-5-(methylsulphonyl)benzoic acid | HCID 2329132 | — |
| Catalyst | Cupric acetate | HCID 8895 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 21217699 | HCID 21217699 | — |
Reaction Steps
A mixture of 2-chloro-5-(methylsulfonyl)benzoic acid (5.0 g, 21.4 mmol), 5-amino-1-ethylpyrazole (2.4 g, 21.4 mmol), DMF (50 ml), Cu(OAc)2 (0.5 g) and K2CO3 (2.76 g, 20 mmol) is heated at reflux overnight. The reaction mixture is poured into water, acidified with acetic acid and extracted with CH2Cl2. The CH2Cl2 layer is evaporated to afford N-(1-ethylpyrazol-5-yl)-5-(methylsulfonyl)anthranilic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05942520 |
| Source dataset | uspto-grants-1999_08 |
| ORD ID | ord-f3f6429c540c4cf1ab9e3dd2ae277565 |
| Source note | uspto-grants-1999_08 |