HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Dimethylformamide → N-(1-ethylpyrazol-5-yl)-4,5-dimethoxyanthranilic acid
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Dimethylformamide | HCID 6228 | — |
| Edukt | Potassium Carbonate | HCID 11430 | — |
| Edukt | 2-Bromo-4,5-dimethoxybenzoic acid | HCID 222963 | — |
| Edukt | 1-Ethyl-1H-pyrazol-5-amine | HCID 337310 | — |
| Katalysator | Cupric acetate | HCID 8895 | — |
| Lösungsmittel | Acetic Acid | HCID 176 | — |
| Lösungsmittel | Water | HCID 962 | — |
| Produkt | N-(1-ethylpyrazol-5-yl)-4,5-dimethoxyanthranilic acid | HCID 21217688 | 97,6% |
Reaktionsschritte
A mixture of 5-amino-1-ethylpyrazole (5.0 g, 45 mmol), 2-bromo-4,5-dimethoxybenzoic acid (11.76 g, 45 mmol), K2CO3 (6.21 g, 45 mmol), Cu(OAc)2 (0.8 g, 400 mmol) and DMF (125 ml) is refluxed overnight. The reaction mixture is cooled, poured into water and acidified with acetic acid. The resulting solid is collected by filtration and dried to afford 12.8 g (97%) of N-(1-ethylpyrazol-5-yl)-4,5-dimethoxyanthranilic acid.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US05942520 |
| Quelldatensatz | uspto-grants-1999_08 |
| ORD ID | ord-f5df32e6af6d40d596175af554282810 |
| Quellennotiz | uspto-grants-1999_08 |