Ammonium Hydroxide → HCID 21217726, compound

Participants

Reaction Steps

A mixture of N-(1-ethylpyrazol-5-yl)-5-(trifluoromethylsulfonyl)anthranilic acid and POCl3 (30 ml) is heated on a steam bath overnight. The reaction mixture is poured onto ice waterl and then is neutralized with NH4OH. The resulting solid is collected by filtration, washed with water, dissolved in CH2Cl2, dried over MgSO4, filtered and stripped. The residue is purified by column chromatography on silica gel eluting with 10% ethyl acetate/hexane to afford 1.0 g of 1-ethyl-4-chloro-6-(trifluoromethylsulfonyl)-1H-pyrazolo[3,4-b]quinoline.

Provenance & Evidence