HCID 54252549, compound → HCID 21217866, compound

Participants

Reaction Steps

Part C. Methyl 3-(3-nitrophenyl)-5-(4-cyanophenyl)-2,4-pentadienoate (0.869 gm, 2.6 mmol) was dissolved in THF and degassed with N2. A catalytic amount of 10% Pd/C was added and the solution was placed on a Parr shaker for 45 min. at 45 p.s.i. The solution was filtered through Celite and the solvent was removed under vacuum. The residue was chromatographed on silica gel eluting ethyl acetate:methylene chloride (20:80, v:v) to give methyl 3-(3-aminophenyl)-5-(4-cyanophenyl)pentanoate as an oil 0.512 gm (64%). 1H NMR (CDCl3): 1.9 (m, 2H), 2.55 (t, 2H), 3.0 (m, 1H), 3.25 (m, 2H), 3.6 (s, 3H), 6.5 (s, 1H), 6.55 (m, 2H), 7.1 (t, 1H), 7.3 (m, 2H), 7.55 (m, 3H).

Provenance & Evidence