Toluene → (R)-2-(2,4-Dichlorophenoxy)propionyl chloride

Participants

Reaction Conditions

Reaction Steps

A stirred mixture of (R)-2-(2,4-dichlorophenoxy)propionic acid (588 g, 2.5 mol), 588 g of toluene and 0.6 g of dimethyl formamide (DMF) is heated to 75° C., treated with thionyl chloride (304 g, 2.55 mol) over a 1.5 hour period, heated at 75° C. for 1 hour and cooled to 20-25° C. The resultant reaction mixture may be distilled to obtain the title product in quantitative yield, as an amber oil, or used as is in the next process step. The isolated product is characterized by NMR analysis. The product toluene solution is assayed by HPLC analysis.

Provenance & Evidence