反应详情

1.025 g of 6-chloropiperonyl chloride, 5 ml of dimethylformamide, 330 mg of potassium cyanide are introduced, agitation is carried out at ambient temperature for 6 hours, the reaction medium is poured into 50 ml of water, extracted with 3×30 ml of ethyl acetate, the extracts are washed with 30 ml of sodium chloride and dried. After recrystallization from 5 ml of isopropyl ether under reflux and separating, 740 mg of expected product (white crystals) is obtained. ANALYSIS: IR CHCl3 cm-1CN 2255 Aromatic 1625-1505-1481

1. extractionextracted with 3×30 ml of ethyl acetate
2. washthe extracts are washed with 30 ml of sodium chloride
3. customdried
4. customAfter recrystallization from 5 ml of isopropyl ether
5. temperatureunder reflux
6. customseparating