反应详情

(2S,3S)-Ethyl 2 ethyl-3-hydroxybutyrate (1 gram) is dissolved in 5 ml of absolute ethanol followed by the addition of 0.5 gram of gaseous ammonia. The solution is kept in a stoppered flask, and the progress of the reaction is followed by thin layer chromatography. After the reaction is judged complete, the ethanol is evaporated and the resulting residue redissolved in ethyl acetate. Ammonia is removed by extraction with 1% HCl, and the ethyl acetate solution is dried over MgSO4, filtered, and rotary evaporated to leave 0.7 grams of (2S,3S)-2 ethyl-3-hydroxybutyramide.

1. customThe solution is kept in a stoppered flask
2. customthe ethanol is evaporated
3. dissolutionthe resulting residue redissolved in ethyl acetate
4. customAmmonia is removed by extraction with 1% HCl
5. dry with materialthe ethyl acetate solution is dried over MgSO4
6. filtrationfiltered
7. customrotary evaporated