Acetyl chloride → N-(2-(Methoxy)-3-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}phenyl)acetamide dihydrochloride

HRID 15864Notes

Reaction equation

HRID 15864 reaction equation
[CH3:1][O:2][C:3]1[C:9]([CH2:10][CH2:11][N:12]2[CH2:17][CH2:16][N:15]([C:18]3[CH:27]=[CH:26][CH:25]=[C:24]4[C:19]=3[CH:20]=[CH:21][C:22]([CH3:28])=[N:23]4)[CH2:14][CH2:13]2)=[CH:8][CH:7]=[CH:6][C:4]=1[NH2:5].[C:29]([Cl:32])(=[O:31])[CH3:30]>>[ClH:32].[ClH:32].[CH3:1][O:2][C:3]1[C:9]([CH2:10][CH2:11][N:12]2[CH2:13][CH2:14][N:15]([C:18]3[CH:27]=[CH:26][CH:25]=[C:24]4[C:19]=3[CH:20]=[CH:21][C:22]([CH3:28])=[N:23]4)[CH2:16][CH2:17]2)=[CH:8][CH:7]=[CH:6][C:4]=1[NH:5][C:29](=[O:31])[CH3:30]

Participants

3

Reactant 2

HCID 6367Acetyl chlorideHCID 574443452-(Methoxy)-3-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}aniline

Product 1

HCID 57478365N-(2-(Methoxy)-3-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}phenyl)acetamide dihydrochlorideYield 42%

Procedure

The title compound was prepared in 42% yield according to the general procedure for the preparation of amides (Method B) starting from starting from 2-(methoxy)-3-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}aniline and acetyl chloride.

Sources & evidence

ORD record
ord-05219615b1ec432f83462321a0f00a50
Source dataset
uspto-grants-2010_06
Patent number
US07732600B2

Reaction notes

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