1-(tert-Butoxycarbonyl)-4-(methanesulfonyloxy)piperidine → 5-phenyl-4-(1-(5-propylpyrimidin-2-yl)piperidin-4-yloxy)pyridin-2(1H)-one

HRID 158640Notes

Reaction equation

HRID 158640 reaction equation
[CH3:15][S:16]([O:17][CH:20]1[CH2:21][CH2:22][N:23]([c:26]2[n:27][cH:28][c:29]([CH2:32][CH2:33][CH3:34])[cH:30][n:31]2)[CH2:24][CH2:25]1)(=[O:18])=[O:19].[CH3:35][S:36]([O:37][CH:38]1[CH2:39][CH2:40][N:41]([C:42]([O:43][C:44]([CH3:45])([CH3:46])[CH3:47])=[O:48])[CH2:49][CH2:50]1)(=[O:51])=[O:52].[OH:1][c:2]1[cH:3][c:4](=[O:14])[nH:5][cH:6][c:7]1-[c:8]1[cH:9][cH:10][cH:11][cH:12][cH:13]1>>[O:1]([c:2]1[cH:3][c:4](=[O:14])[nH:5][cH:6][c:7]1-[c:8]1[cH:9][cH:10][cH:11][cH:12][cH:13]1)[CH:20]1[CH2:21][CH2:22][N:23]([c:26]2[n:27][cH:28][c:29]([CH2:32][CH2:33][CH3:34])[cH:30][n:31]2)[CH2:24][CH2:25]1

Participants

4

Reactant 3

HCID 41848691-(tert-Butoxycarbonyl)-4-(methanesulfonyloxy)piperidineHCID 546832584-Hydroxy-5-phenylpyridin-2(1H)-oneHCID 866262675-Propylpyrimidin-2-ylpiperidin-4-yl methanesulfonate

Product 1

HCID 673696175-phenyl-4-(1-(5-propylpyrimidin-2-yl)piperidin-4-yloxy)pyridin-2(1H)-one

Sources & evidence

ORD record
ord-041adbb43aaa4062b264e81c971cfbb4
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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