Acetonitrile → 1-Butylpiperazine
Reaction equation
BrC[CH2:3][CH2:4][N:5]1[C:9](=O)[C:8]2=CC=[CH:13][CH:14]=[C:7]2[C:6]1=O.C(#[N:18])C>>[CH2:6]([N:5]1[CH2:9][CH2:8][NH:18][CH2:3][CH2:4]1)[CH2:7][CH2:14][CH3:13]Participants
3
Procedure
N-(3-Bromopropyl)phthalimide (15.1 g) was dissolved in acetonitrile (100 ml), and 1-n-butylpiperazine (5.33 g) obtained in Preparation Example 1 and 50% potassium fluoride-Celite (21.8 g) were added at room temperature. After stirring overnight, the reaction solution was filtered off with Celite, and the solvent was distilled off under reduced pressure. The residue obtained was purified by silica gel column chromatography (methylene chloride:methanol=95:5) to give the title compound (9.83 g) as a yellow oily substance. Yield=80%.
Sources & evidence
- ORD record
- ord-9d2436e2f97f4b7aae4198096535c480
- Source dataset
- uspto-grants-1999_08
- Patent number
- US05945434
Reaction notes
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