Hydrazine → HCID 88438518, compound

HRID 1586499Notes

Reaction equation

[CH3:1][C:2]1[C:7]([O:8][CH3:9])=[C:6]([CH3:10])[C:5]([CH2:11][S:12]([C:14]2[N:18]([CH2:19][CH3:20])[C:17]3[CH:21]=[C:22]([Cl:25])[CH:23]=[CH:24][C:16]=3[N:15]=2)=[O:13])=[C:4]([N:26]2[C:30](=[O:31])[C:29]3=[CH:32][CH:33]=[CH:34][CH:35]=[C:28]3[C:27]2=[O:36])[CH:3]=1.[NH2:37][NH2:38]>>[Cl:25][C:22]1[CH:23]=[CH:24][C:16]2[N:15]=[C:14]([S:12]([CH2:11][C:5]3[C:6]([CH3:10])=[C:7]([O:8][CH3:9])[C:2]([CH3:1])=[CH:3][C:4]=3[NH:26][C:27]([C:28]3[CH:35]=[CH:34][CH:33]=[CH:32][C:29]=3[C:30]([NH:37][NH2:38])=[O:31])=[O:36])=[O:13])[N:18]([CH2:19][CH3:20])[C:17]=2[CH:21]=1

Participants

Reactant 2

HCID 9321Hydrazine

HCID 54014596HCID 54014596, compound

Product 1

HCID 88438518HCID 88438518, compound

Procedure

The title compound of Example 122 (65 mg, 0.12 mmol) was treated with hydrazine according to the general procedure of Example 39 to give 48 mg (100%) of the partially deprotected amine title compound. 1H NMR (CDCl3) δ1.31 (t, 3H), 2.28 (s, 3H), 2.32 (s, 3H), 3.65 (s, 3H), 4.16 (s, 1H), 4.32 (m, 2H), 4.48 (q, 2H), 7.19 (s, 1H), 7.31 (m, 1H), 7.49 (s, 1H), 7.59 (m, 2H), 7.70 (m, 1H), 7.80 (m, 2H).

Sources & evidence

ORD record: ord-236d447677bd4ccaa1da9d1c84d891e6
Source dataset: uspto-grants-1999_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05945425

Reaction notes

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