Hydrazine → HCID 88439159, compound

Participants

Reaction Steps

2-[(4,6-Dimethyl-5-methoxy-2-phthalimidylphenyl)methylsulfinyl]-5-chloro-1-ethyl-1H-benzimidazole (Example 121) (66 mg, 0.13 mmol) was treated with hydrazine according to the procedure of Example 39 to give the crude acyl hydrazide as an oil which was triturated with ether to give the partially deprotected amine as the title compound (28 mg, 57%). 1H NMR δ1.29, (t, 3H), 2.26 (s, 3H), 2.34 (s, 3H), 3.66 (s, 3H), 4.16 (s, 2H), 4.29 (m, 2H), 4.95 (q, 2H), 7.24 (s, 2H), 7.37 (s, 1H), 7.48 (s, 1H), 7.55 (m, 2H), 7.69 (m, 1H), 7.82 (m, 1H), 7.87 (s, 1H).

Provenance & Evidence