Methanol → HCID 21900999, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 170.3 g of 1,4-bis(mercaptomethyl)-benzene and 185.1 g of epichlorohydrin was cooled to 10° C., and 40 ml of methanol and an aqueous solution obtained by dissolving 0.4 g of an aqueous sodium hydroxide solution in 4 ml of water were added to the cooled solution, followed by stirring at this temperature for 1 hour. Afterward, an aqueous solution obtained by dissolving 80.0 g of sodium hydroxide in 80 ml of water was added thereto, while a solution temperature was maintained at about 0 to 10° C., followed by stirring for 3 hours at this temperature. Next, 200 ml of water was added to the reaction mixture, and extraction was carried out with 300 ml of toluene. The resulting toluene layer was dried over sodium sulfate, and the used solvent was distilled off to obtain 275.8 g (97% of a theoretical amount) of 1,4-bis(glycidylthiomethyl)benzene in the state of a colorless transparent liquid.

Provenance & Evidence