Dichloromethane → HCID 21217011, compound

Participants

Reaction Steps

A 250 mL 3 neck round-bottom flask equipped with a condenser was flushed with nitrogen and then loaded with 1,4-bis(hydroxymethyl)-2,3-di-(4-fluorophenyl)-benzene (2.70 g, 8.28 mmol), thionyl chloride (2.20 g, 18.5 mmol), methylene chloride (90 mL) and 3 drops of pyridine. The solution was then refluxed overnight and then cooled to room temperature. Methylene chloride was removed by rotary evaporation and then methanol was added to precipitate out the white product (0.77 g, 26% yield).

Provenance & Evidence