Dichloromethane → HCID 21217015, compound

Participants

Reaction Steps

A 250 mL 3 neck round-bottom flask equipped with a condenser was flushed with nitrogen and then loaded with 5-hexyl-1,4-bis(hydroxymethyl)-2,3-di(4-fluorophenyl)-benzene (1.35 g, 3.3 mmol), thionyl chloride (7 g, 58.8 mmol) and methylene chloride (10 mL) was stirred at room temperature for 1 hour, and then refluxed for an additional 2 hour, and finally stirred at room temperature overnight. The solvent was then removed by rotary evaporation to give a pale yellow oil (1.1 g, 74.7% yield).

Provenance & Evidence