HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chloride → (2S)-N-(1,1-Dimethylethyl)piperazine-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chloride | HCID 312 | — |
| Reactant | N-tert-butylpyrazine-2-carboxamide | HCID 4462842 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | (2S)-N-(1,1-Dimethylethyl)piperazine-2-carboxamide | HCID 9806153 | — |
Reaction Steps
Analogously to Example 4, 5 g (27 mmol) of pyrazinecarboxylic acid tert-butylamide, 127 mg (0.27 mmol) of bicyclo[2.2.1]hepta-2,5-dienerhodium(I) chloride dimer and 353 mg (0.594 mmol) of 1-[1 (R)-(dicyclohexylphosphino)ethyl]-2(S)-(diphenylphosphino)ferrocene were hydrogenated for 20 hours in 70 ml of methanol at 100° C. and 50 bar. A conversion of 85 percent was determined by NMR. The enantiomeric excess (ee) was 49 percent according to GC analysis.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05945534 |
| Source dataset | uspto-grants-1999_08 |
| ORD ID | ord-9c9c268ad2a4414e864801ba4d54cfe8 |
| Source note | uspto-grants-1999_08 |