HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(1-methyl-1H-indol-3-yl)acetic acid → Indole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(1-methyl-1H-indol-3-yl)acetic acid | HCID 254166 | — |
| Reactant | HCID 21216820 | HCID 21216820 | — |
| Reactant | HCID 23221070 | HCID 23221070 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | Indole | HCID 798 | — |
| Product | 1,8-Diazabicyclo(5.4.0)undec-7-ene | HCID 81184 | — |
| Product | Crotononitrile | HCID 637921 | — |
| Product | HCID 23221070 | HCID 23221070 | — |
Reaction Steps
12-(3-cyano-2-propyl)-6,7,12,13-tetrahydro-13-methyl-5,7-dioxo-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole; yellow crystals which decompose from about 270° C. The 3-[1-(3-cyano-2-propyl)-3-indolyl]-4-(1-methyl-3-indolyl)-1H-pyrrol-3,5-dione used as starting material (red amorphous powder; decomp. point about 218-226° C.) is prepared analogously to EP 0 328 026 from 1-(3-cyano-2-propyl)-indole and 1-methyl-3-indolylacetic acid. 1-(3-Cyano-2-propyl)-indole is prepared in low yield by the base-catalysed (DBU) addition of crotonitrile to indole in acetonitrile.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05945440 |
| Source dataset | uspto-grants-1999_08 |
| ORD ID | ord-975aa7579775426e8ea68a4dfcf58ccf |
| Source note | uspto-grants-1999_08 |