Acetone → HCID 19758718, compound

Participants

Reaction Steps

A mixture of the bromoester from (a) (55.3 g, 0.19 mol), 4-hydroxyacetophenone (25.7 g, 0.19 mol) and potassium carbonate (26.1 g, 0.19 mol) in acetone (250 ml) was heated to reflux with stirring for 2 days. After cooling to room temperature, water (500 ml) was added and the whole mixture extracted with ethyl acetate (3×300 ml). The combined extracts were then washed with 3N sodium hydroxide solution (300 ml), water (2×300 ml), 3N HCl solution (200 ml) and water (2×300 ml). After drying over MgSO4 the solvent was removed by evaporation under reduced pressure and the residue recrystallized from methanol to give a white solid (42.9 g, 65%).

Provenance & Evidence