Benzenamine, 2-chloro-5-(trifluoromethyl)- → HCID 19758719, compound

Participants

Reaction Conditions

Reaction Steps

A solution of the product from (c) (47 g, 0.112 mol) and 3-amino-4-chlorobenzotrifluoride (21.9 g, 0.112 mol) in xylene (450 ml) were heated to reflux for 5 h. Over the final hour, the volume of the mixture was reduced to 200 ml by distillation. After cooling to about 80° C., the solution was poured into petrol (b.p. 60°-80° C. (1 liter) with rapid stirring. A pale yellow solid was collected by filtration and then recrystallized from petrol (b.p. 60°-80° C.) to give an off white solid (40.5 g, 63%).

Provenance & Evidence