Dimethylamine → 1-(N,N-dimethylcarbamoylmethyl)-1H-imidazo[1,2-b]-pyrazole

Participants

Reaction Steps

To a solution of 1-ethoxycarbonylmethyl-1H-imidazo-[1,2-b]pyrazole (7.0 g) in ethanol (35 ml) was added 50% dimethylamine aqueous solution (17 ml). The mixture was stirred at room temperature for 5 hours. The reaction mixture was evaporated in vacuo. The resultant crude powder was subjected to column chromatography on silica gel using a mixture of ethyl acetate and methanol as an eluent. Fractions containing the object compound were combined and evaporated in vacuo. The resultant precipitate was collected and washed with diisopropyl ether to give 1-(N,N-dimethylcarbamoylmethyl)-1H-imidazo[1,2-b]-pyrazole (1.6 g).

Provenance & Evidence