Ethanol → 8-(3,4-Difluorophenyl)-N-(1-(2-ethoxypyridin-4-yl)piperidin-4-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine

HRID 158667Notes

Reaction equation

HRID 158667 reaction equation
[CH3:33][CH2:34][O-:35].[CH3:36][CH2:37][OH:38].[Cl:1][c:2]1[n:3][cH:4][cH:5][c:6]([N:8]2[CH2:9][CH2:10][CH:11]([NH:14][c:15]3[n:16][n:17]4[c:18]([c:19](-[c:23]5[cH:24][c:25]([F:30])[c:26]([F:29])[cH:27][cH:28]5)[cH:20][cH:21][cH:22]4)[n:31]3)[CH2:12][CH2:13]2)[cH:7]1.[Na+:32]>>[c:2]1([O:35][CH2:34][CH3:33])[n:3][cH:4][cH:5][c:6]([N:8]2[CH2:9][CH2:10][CH:11]([NH:14][c:15]3[n:16][n:17]4[c:18]([c:19](-[c:23]5[cH:24][c:25]([F:30])[c:26]([F:29])[cH:27][cH:28]5)[cH:20][cH:21][cH:22]4)[n:31]3)[CH2:12][CH2:13]2)[cH:7]1

Participants

5

Reactant 4

HCID 702EthanolHCID 923Sodium ionHCID 1194401-Hydroxyethyl radicalHCID 58398048N-(1-(2-Chloropyridin-4-yl)piperidin-4-yl)-8-(3,4-difluorophenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine

Product 1

HCID 583980458-(3,4-Difluorophenyl)-N-(1-(2-ethoxypyridin-4-yl)piperidin-4-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine

Sources & evidence

ORD record
ord-a395b4490baa4fe69e300f75cd1bb5d2
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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